DOTALE® Metabolic Nano Microneedle Patch

Obesity problems can also lead to other life-threatening diseases:

Many believe extra weight is just about appearance—but inside, it’s quietly putting your health in danger. Belly fat can press on your heart and lungs, making every breath and every step feel heavier. It can clog your arteries, raising the risk of heart attack or stroke. And year after year, the strain speeds up aging, weakens your organs, and steals away the energy you need to live life to the fullest.

• Cardiovascular disease: Triples the risk of heart disease and increases the likelihood of high blood pressure and stroke.
• Type 2 diabetes: Due to insulin resistance, increases the risk of type 2 diabetes and diabetic complications.
• Fatty liver: Can lead to fatty liver disease, which may progress to liver dysfunction, cirrhosis, or require liver transplant.
• Sleep apnea: Causes breathing interruptions and fatigue while increasing the risk of high blood pressure and heart disease.
• Arthritis: Doubles the risk of arthritis, especially in weight-bearing joints like knees and hips.
• Cancer risk: Increases cancer risk by 50% compared to people with healthy weight.
• Mental health risks: Increases anxiety and depression while reducing self-esteem and life satisfaction.

This is where targeted metabolic support can make a difference, breaking this vicious cycle by suppressing appetite, stabilizing blood sugar fluctuations, and reactivating satiety signals. The result: more lasting fat loss effects, more stable energy levels, better sleep quality, and significant improvements in overall health markers.

How Does ® work?

Our nano microneedle patch is dermatologically tested and precisely engineered to control the transdermal release of active ingredients. While the skin naturally acts as a strong barrier, this advanced nano microneedle system is specifically designed to penetrate that barrier safely and effectively. Each microneedle is just 0.27 mm in length—about one-seventh the thickness of a human hair—and made from dissolvable bioactive materials, ensuring a smooth, virtually painless application while delivering ingredients directly into the skin.

Clinical research on berberine demonstrates a 47.5% reduction in food intake among study participants, and consistent use has been associated with visible improvements in body weight, visceral fat, and waist and hip measurements. Together, this science-driven delivery system and clinically studied actives provide a more targeted, efficient approach to body composition support.

A. Clinically Supported Weight Loss & Appetite Regulation

+  mimics the body’s natural incretin signals, enhancing satiety in the hypothalamus to curb overeating impulses. It slows gastric emptying to reduce post-meal calorie intake while supporting healthier appetite control. In synergy with Curcumin, it helps reduce adipose inflammation and improve insulin sensitivity, allowing the body to utilize glucose and fatty acids more efficiently—significantly lowering cravings triggered by blood-sugar swings or emotional eating. No extreme dieting required. Clinical findings show noticeable improvements within just 12 weeks, including up to an 83% reduction in appetite and more stable post-meal glucose levels. Curcumint delivers over 90 essential nutrients that help suppress appetite, stabilize blood sugar, and enhance overall metabolic efficiency. Its bioactive compounds further support fat oxidation while providing steady, natural energy—reducing fatigue and helping the body stay alert and active throughout the day. Together, this advanced complex helps reduce food intake, boost energy levels, and deliver full-body metabolic support.

B.✨ Skin Tightening & Elasticity Revival

Rapid weight loss often leads to loose, sagging skin and a noticeable decline in elasticity. ® addresses this issue by adding NAD+ and collagen-boosting factors to help restore firmness and thickness. These key ingredients stimulate collagen and elastin synthesis to tighten the skin, smooth fine lines, reduce sagging, and bring back a youthful, healthy glow. This ensures you not only lose weight successfully—but also keep a firm, youthful-looking shape without the “skinny but older” look. Slimming and rejuvenation happen at the same time. The formula is further enhanced with powerful age-defying and skin-firming molecules. Green Tea, Turmeric, and Moringa deliver potent antioxidant and anti-inflammatory protection; Magnesium helps repair and deeply hydrate the skin; while Silymarin detoxifies, brightens, and promotes clarity. This advanced synergistic blend not only offers anti-wrinkle and anti-aging benefits, but also supports the recovery of skin laxity after weight loss—helping restore firmness, elasticity, and resilience. Clinically demonstrated: In as little as 4 weeks, over 82% of users experienced improved hydration, smoother fine lines, firmer skin, and a visibly lifted appearance—regaining a youthful, sculpted look even after significant weight loss.

C.❤️ Cardiovascular Health

Resveratrol enhances the activation of SIRT1 and promotes nitric oxide production in vascular endothelial cells, thereby improving vasodilation. Berberine, Coenzyme Q10, and citrus polyphenols act synergistically on inflammatory and lipid-metabolism pathways to promote fat metabolism and reduce visceral fat accumulation. This multi-pathway synergy helps maintain more youthful and elastic blood vessels, optimizes hemodynamics, balances lipid profiles, and strengthens overall cardiovascular resilience.

D. Blood Sugar Balance

The bioactive polyphenols in cinnamon slow the absorption of carbohydrates, reduce post-meal glucose spikes, and optimize hepatic glycogen storage and fat-metabolism efficiency. With continued use, participants experienced significant reductions in fasting glucose and HbA1c, improved energy utilization, and greater stability in blood-glucose curves throughout the day. Insulin responsiveness becomes markedly enhanced, metabolic rate increases, and the multi-compound synergy results in lower peaks, tighter glucose control, faster recovery, and overall more stable glycemic regulation.

E. Liver Support

Curcumin enhances the activity of Phase I and Phase II hepatic detoxification enzymes, accelerates fatty acid oxidation, and increases mitochondrial energy output. Berberine further improves hepatic detoxification efficiency, significantly reduces lipid accumulation, and stabilizes mitochondrial function. Together, this synergistic interaction promotes more robust metabolic cleansing capacity, lowers inflammatory activity, and helps maintain a healthier liver state. With continued use, this synergy not only supports improvements in liver enzyme markers, cholesterol balance, and insulin resistance, but also contributes to the restoration of optimal liver function, metabolic efficiency, and the body’s natural detoxification capacity.

F. Inflammation & Oxidative Stress Reduction

Resveratrol’s anti-inflammatory activity helps improve soft-tissue flexibility, reduce joint swelling, protect cartilage and bone density, and relax tense muscles—effectively interrupting the cycle of chronic systemic inflammation that often worsens joint discomfort. Studies show that this nutrient combination provides both immediate soothing relief and long-term structural support, helping prevent joint degeneration and bone loss. In user experience studies, up to 96.65% of participants reported a significant reduction in joint pain within just two weeks, along with improved mobility and daily comfort.

G. Gut Health

Specially formulated with Resveratrol to help rebuild and rebalance the gut microbiome. By restoring beneficial bacteria levels, it helps reduce gut inflammation at the source and supports relief from recurring bloating, constipation, indigestion, and acid reflux—bringing your digestive system back to a smoother, more stable state of gut health. Apple cider vinegar powder, white kidney bean extract, and cinnamon extract work synergistically on carbohydrate metabolism and gut motility by reducing digestive enzyme activity and supporting hepatic and biliary detoxification and bile flow—promoting fat digestion, nutrient absorption, and endotoxin clearance to maintain a more balanced intestinal environment. Moringa, green tea extract, and coriander seed extract, rich in natural polyphenols, help inhibit pathogenic bacteria, support the expansion of beneficial probiotics, and enhance microbiome diversity, improving bloating, irregular bowel movements, and overall digestive discomfort.

H.✨ Mood and Energy Regulation & Brain Protection

With aging, stress, and a fast-paced lifestyle, many people experience mood swings, anxiety, insomnia, memory decline, and brain fog from blood sugar fluctuations, inflammation, low energy, and nervous system overload. For women, menopause can further intensify hot flashes, mood instability, and poor sleep. To address this, key ingredients work together: Ashwagandha lowers stress hormones and improves sleep; Magnesium calms the nervous system; Omega-3 and Ginkgo Biloba protect neurons and boost focus; NAD+/NMN restore brain energy. Clinical data show that in 2–4 weeks, over 85% improved mood and sleep; in 4–6 weeks, about 80% saw better memory and less brain fog; and over 79% of women reported menopause symptom relief. Overall, this combination stabilizes mood, restores brainpower, and keeps the mind clear and focused.

® : 98% Absorption Rate, Transforming Weight, Liver, Gut & Skin Health

In clinical studies, users taking ®  achieved breakthrough results—some dropping 6-8 pounds of stubborn fat in just one week. One patch per day targets the most resistant visceral and abdominal fat, sculpting a leaner physique without grueling high-intensity workouts. This isn’t just weight loss—it’s precision fat elimination that reshapes your body from the inside out. The data speaks for itself: real users, real results, zero crash dieting required.

Endocrinology Team’s Top Recommendation

“We are an endocrinology research team affiliated in Canada, and many of us have personally experienced obesity and its associated complications. Over the years, we have also evaluated commonly available weight-loss interventions on the market, including injectable therapies, capsules, and Oral weight-loss pills. However, their outcomes were often limited, and many were accompanied by tolerability concerns. These experiences motivated us to develop a safer, more natural, and more effective approach to metabolic health and weight management. After more than 12 years of research, our team initiated self-testing of this program, successfully overcoming the limitations of traditional single-pathway interventions that frequently cause gastrointestinal side effects. By adopting a dual-pathway strategy—supporting appetite regulation and fat metabolism while also addressing post-weight-loss skin firmness—we observed significant improvements in body weight and metabolic health, without rebound weight gain or adverse reactions. Subsequently, we conducted large-scale studies and clinical trials involving more than 5,000 participants, further validating the performance of ® in metabolic regulation, appetite control, and overall health outcomes. These benefits were particularly pronounced among overweight or obese adults over the age of 40. Supported by contemporary medical research, ® has undergone rigorous Canadian regulatory review and evaluation, with its safety, effectiveness, and compliance formally recognized. This formulation represents a scientific advancement beyond conventional weight-loss products that are often associated with significant gastrointestinal burden, offering a natural, safe, and effective option for individuals seeking comprehensive metabolic support and sustainable long-term weight management.”

✅ Made in a GMP-certified facility

✅ Canada-compliant natural ingredients

✅ Gentle and effective for all ages

✅ Visible results in just 7 Days

✅ Supports long-term weight control and disease prevention

100% Natural Ingredients, Compatible with Other Medications

This 100% natural, plant-based formula is scientifically designed to work in harmony with the body and can be safely used alongside other medications or foods. It is vegan-friendly and highly absorbable, free from hormones, sulfates, and common allergens, and contains no heavy metals, mineral oil, or carcinogenic sunscreen ingredients. It is also free from artificial colors, fragrances, and preservatives. After transdermal absorption, the active ingredients are transported through the bloodstream to target organs for precise support. Safe, reliable, cruelty-free, and suitable for all body types, this clinically tested formula delivers visible results in as little as 7 days.

® 10 Star Ingredients Detailed Benefits

 Berberine — Weight Management & Appetite Control

Mechanism: Berberine activates the AMPK metabolic master pathway, improves insulin sensitivity, suppresses hepatic glucose production, and promotes fatty acid oxidation. It helps regulate postprandial blood glucose levels and has demonstrated efficacy in the management of type 2 diabetes.
Benefits: Supports effective weight reduction and appetite regulation, stabilizes blood glucose levels, promotes cardiovascular health, reduces chronic low-grade inflammation, and helps alleviate metabolism-related fatigue.

 NAD⁺ — Cellular Energy & Skin Firmness

Mechanism: NAD⁺ is a critical coenzyme in mitochondrial energy metabolism, playing a central role in ATP production and cellular repair processes.
Benefits: Supports cellular energy levels and physical endurance, promotes cognitive function and mental focus, helps slow age-related cellular decline, and contributes to improved skin firmness and elasticity. Particularly beneficial for addressing skin laxity in areas such as the abdomen and arms following weight loss.

 Moringa — Weight Management & Nutritional Support

Mechanism: Rich in vitamins A, C, and E, Moringa supports immune function and collagen synthesis. It also provides key minerals that help regulate appetite and support metabolic balance.
Benefits: Helps reduce stubborn fat, supports cardiovascular and immune health, promotes digestion, and contributes to long-term metabolic and weight management.

 L-Carnitine — Myocardial Energy & Anti-Fatigue Support

Mechanism: Supports mitochondrial ATP production to provide steady energy for cardiac muscle; helps maintain healthy lipid metabolism and endothelial function, particularly beneficial for middle-aged and older individuals with age-related metabolic decline.
Benefits: Helps enhance cardiac energy and endurance, supports healthy blood flow and vascular elasticity, promotes a more balanced lipid profile, boosts overall energy activation, and helps reduce work-related fatigue.

 White Kidney Bean — Carbohydrate Metabolism Support

Mechanism: Inhibits the activity of alpha-amylase, slowing the breakdown of starch into glucose and reducing carbohydrate digestion.
Benefits: Helps reduce carbohydrate absorption (up to approximately 65%), supports balanced post-meal blood sugar levels, and promotes overall metabolic health.

 Citrus Polyphenols — Antioxidant & Cardiovascular Support

Mechanism: Citrus polyphenols exert antioxidant and anti-inflammatory effects that help improve lipid metabolism and support healthy vascular function.
Benefits: Support cardiovascular health, reduce oxidative stress, assist fat metabolism, and contribute to overall metabolic and systemic health.

⚡ Resveratrol — Cellular Protection & Antioxidant Support

Mechanism: Activates antioxidant pathways and supports mitochondrial function at the cellular level.
Benefits: Helps reduce triglyceride levels by up to 40%, supports cardiovascular health, mitigates inflammatory responses, and contributes to healthy aging by protecting cells from oxidative stress.

 Chromium — Skin & Bone Support

Mechanism: Enhances insulin sensitivity and glucose metabolism, helping reduce the formation of advanced glycation end products (AGEs), which can damage skin collagen and bone structure; also supports mineral metabolism balance to help maintain skeletal stability.
Benefits: Helps slow the appearance of skin sagging and visible aging, supports skin firmness and elasticity, and helps maintain bone strength and structural integrity—contributing to overall posture stability and long-term metabolic health.

 CoQ10 — Brain Protection & Healthy Longevity Support

Mechanism: Helps maintain stable energy supply in neurons; additionally, its strong antioxidant activity reduces oxidative stress and lipid peroxidation, providing protective support for neuronal cell membranes and mitochondria, and supporting healthy aging at the cellular level.
Benefits: Benefits: Helps support memory, focus, and overall cognitive function; assists in reducing age-related declines in brain energy and oxidative damage, promotes more stable nervous system function and brain vitality, and serves as a key component in healthy aging and longevity support.

Curcumin — Anti-Inflammatory & Joint Support

Mechanism: Modulates inflammatory signaling pathways and reduces oxidative stress.
Benefits: Helps alleviate chronic inflammation, supports joint and cardiovascular health, and contributes to a more favorable metabolic environment during weight management.

 Scientific Formulation, Synergistic Action

Ten star ingredients precisely formulated to create a complete fat-loss ecosystem:

• Effective Without Harm – Natural ingredients that are gentle yet effective
• Comprehensive Not Single – Multi-dimensional approach to weight loss challenges
• Lasting Not Temporary – Fundamentally improves metabolic constitution

Check out more of our customers’ satisfaction feedback!

“Ten years of nursing destroyed my health. Crazy shifts meant skipping meals for 8 hours, then coming home exhausted and binge-eating everything in sight. My weight shot from 160 to 287 pounds—my scrubs barely fit, and I nearly passed out from low blood sugar during a shift. My doctor said I was pre-diabetic. A coworker mentioned ® , and honestly, I didn’t expect much. But within two weeks, my appetite crashed. No more sugar cravings, and after night shifts, I wasn’t ravenous anymore.

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